Abstract
THE cellular immune response to murine sarcoma virus (MSV)-induced tumours in mice involves lymphoid effector cells of different origins1,2. When the chromium release test (CRT)3–5 is used to study this immune response, only thymus-derived lymphoid cells (T cells) show any appreciable lytic activity towards the appropriate tumour target cells6,7. Other lymphoid cells display no lytic activity in CRT, nor are they required for T cell-dependent tumour cell lysis to occur7. When the micro-cytotoxicity assay (MA) of Takasugi and Klein8 is used to study the cellular immune response of the same MSV tumour-bearing mice, both T and non-T lymphoid cells are seen to be active1,2.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Plata, F., Gomard, E., Leclerc, J. C., and Levy, J. P., J. Immun., (in the press).
Lamon, E. W., Wigzell, H., Klein, E., Anderson, B., and Skurzak, H. M., J. exp. Med., 137, 1472 (1973).
Cerottini, J. C., Nordin, A. A., and Brunner, K. T., Nature, 228, 1308 (1970).
Leclerc, J. C., Gomard, E., and Levy, J. P., Int. J. Cancer, 10, 589 (1972).
Laverin, D., Nunn, M., and Herberman, R. B., Proc. Am. Ass. Cancer Res., 13, 66 (1972).
Leclerc, J. C., Gomard, E., Plata, F., and Levy, J. P., Int. J. Cancer, 11, 426 (1973).
Plata, F., Gomard, E., Leclerc, J. C., and Levy, J. P., J. Immun., 11, 667 (1973).
Takasugi, M., and Klein, E., Transplantation, 9, 219 (1970).
Hellström, I., and Hellström, K. E., Int. J. Cancer, 5, 195 (1970).
Baldwin, R. W., Price, M. R., and Robins, R. A., Int. J. Cancer, 11, 527 (1973).
Baldwin, R. W., Bowen, J. G., and Price, M. R., Br. J. Cancer, 28, 16 (1973).
Sjögren, H. O., Hellström, I., Bansal, S. C., and Hellström, K. E., Proc. natn. Acad. Sci., U.S.A., 68, 1372 (1971).
Mettzer, M. S., Leonard, E. J., Rapps, H. J., and Borsos, T. W., J. natn., Cancer Inst., 47, 703 (1971).
Reisfeld, R. A., Pellegrino, M. A., Kahan, B. D., Science, 172, 1134 (1971).
Boyse, E. A., Old, L. J., and Stockert, E., Nature, 201, 777 (1964).
Wigzell, H., Sundqvist, K. G., and Yoshiva, T. O., Scand. J. Immun., 1, 75 (1972).
Wagner, H., and Boyle, W., Nature new Biol., 240, 92 (1972).
Brunner, K. T., Nordin, A. A., and Cerottini, J. C., in Cellular Interactions in the Immune Response (edit. by Cohen, S., Cudkowicz, G., and McCluskey, R. T.), 220–230 (S. Karger, Bassel, 1971).
Cantor, H., and Asofsky, R., J. exp. Med., 135, 764 (1972).
Segal, S., Cohen, I. R., and Feldman, M., Science, 175, 1126 (1972).
Stobo, J. D., Paul, W. E., and Henney, C. S., J. Immun., 110, 652 (1973).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PLATA, F., LEVY, J. Blocking of syngeneic effector T cells by soluble tumour antigens. Nature 249, 271–274 (1974). https://doi.org/10.1038/249271a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/249271a0
This article is cited by
-
A one-receptor view of T-cell behaviour
Nature (1981)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.