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Human lymphocyte-dependent antibody mediated cytotoxicity and direct lymphocyte cytotoxicity against non-HL-A antigens

Nature volume 249, pages 263–265 (1974)Cite this article

Abstract

EXPRESSION of the major transplantation antigens in humans is generally considered to be controlled by the genes of the HL-A region1–4. Skin, kidney and bone marrow transplants usually survive longer when donors and recipients are HL-A identical than when they are not5–7. However, the fact that grafts are still rejected with HL-A identity and negative mixed lymphocyte reactivity (MLR)8–11 strongly suggests the presence of minor transplantation antigens. The major problem to date has been the development of in vitro assay systems to detect these antigens.

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Authors and Affiliations

  1. Immunology Branch, National Cancer Institute,

    ISRAEL YUST, JOHN WUNDERLICH, DEAN L. MANN & G. N. ROGENTINE JUN.

  2. Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, 20014

    BRIGID LEVENTHAL, RONALD YANKEE & ROBERT GRAW

Authors
  1. ISRAEL YUST
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  2. JOHN WUNDERLICH
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  4. G. N. ROGENTINE JUN.
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  7. ROBERT GRAW
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YUST, I., WUNDERLICH, J., MANN, D. et al. Human lymphocyte-dependent antibody mediated cytotoxicity and direct lymphocyte cytotoxicity against non-HL-A antigens. Nature 249, 263–265 (1974). https://doi.org/10.1038/249263a0

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