Abstract
SEVERAL studies have reported that there is a loss of dendritic spines after partial deafferentation. It is known that terminals lost to a structure after injury to one of its afferents are replaced in part or whole by sprouting of undamaged inputs1–3. This raises questions as to the nature of the accompanying post-synaptic changes but no attempts have been made to follow the loss of spines over time4–6. Specifically, there are no data on whether spines are replaced when sprouting afferents invade deafferented dendritic zones. This is a critical question if the nature of the morphological reorganisation which follows lesions in the brain is to be understood.
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PARNAVELAS, J., LYNCH, G., BRECHA, N. et al. Spine Loss and Regrowth in Hippocampus following Deafferentation. Nature 248, 71–73 (1974). https://doi.org/10.1038/248071a0
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DOI: https://doi.org/10.1038/248071a0
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