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Effects of Low-dose X-irradiation on Chromosomal Non-disjunction in Aged Mice

Abstract

THE factors responsible for the increasing incidence of offspring with Down's syndrome in older women are a continuing subject of debate. The demonstration of a greater frequency of aneuploid embryos in old mice1,2 may open the way for further experimental studies of the causes of some types of chromosomally abnormal conceptuses.

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GOSDEN, R., WALTERS, D. Effects of Low-dose X-irradiation on Chromosomal Non-disjunction in Aged Mice. Nature 248, 54–55 (1974). https://doi.org/10.1038/248054a0

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