Abstract
VESICULAR stomatitis virus (VSV) particles contain an RNA-dependent RNA polymerase which gives rise in vitro to RNA molecules of the same size and polarity as the mRNA found in vivo1–3. It is not clear which structural protein(s) represents the enzymatic activity. Only five proteins (L, G, N, MS, and M, with possibly some additional minor constituents) are detected in the virions4, and several studies have suggested that neither the G protein (glycoprotein surface spike) nor the M protein (membrane protein), nor even associated membrane lipids are necessary for transcriptase activity5–7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Baltimore, D., Huang, A. S., and Stampfer, M., Proc. natn. Acad. Sci. U.S.A., 66, 572 (1970).
Bishop, D. H. L., and Roy, P., J. molec. Biol., 57, 513 (1971).
Huang, A. S., Baltimore, D., and Stampfer, M., Virology, 42, 946 (1970).
Wagner, R. R., Prevec, L., Brown, F., Summers, D. F., Sokol, F., and MacLeod, R., J. Virol., 10, 1228 (1972).
Emerson, S. U., and Wagner, R. R., J. Virol., 10, 297 (1972).
Bishop, D. H. L., and Roy, P., J. Virol., 10, 234 (1972).
Szilagyi, J. F., and Uryvayev, L., J. Virol., 11, 279 (1973).
Perrault, J., and Holland, J., Virology, 50, 148 (1972).
Blatti, S. P., Ingles, C. J., Lindell, T. J., Morris, P. W., Weaver, R. F., Weinberg, F., and Rutter, W. J., Cold Spring Harbor Symp. Quant. Biol., 35, 649 (1970).
Perrault, J., and Holland, J., Virology, 50, 159 (1972).
Cartwright, B., Talbot, P., and Brown, F., J. gen. Virol., 7, 267 (1970).
Wagner, R. R., Snyder, R. M., and Yamazaki, S., J. Virol. 5, 548 (1970).
Mudd, J. A., and Summers, D. F., Virology, 42, 328 (1970).
Astell, C., Silverstein, S. C., Levin, D. H., and Acs, G., Virology, 48, 648 (1972)c.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
PERRAULT, J., KINGSBURY, D. Inhibitor of vesicular stomatitis virus transcriptase in purified virions. Nature 248, 45–47 (1974). https://doi.org/10.1038/248045a0
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1038/248045a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
