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Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate

Nature volume 248, pages 24–27 (1974)Cite this article

Abstract

In homogenate of rat brain, morphine, at concentrations obtainable in vivo, inhibited the stimulation by prostaglandin E1 or E2 of cyclic AMP formation, without inhibiting the basal production of cyclic AMP. Heroin was more atnd methadone less active than morphine, whereas dextrorphan was inactive and naloxone antagonised the effect of morphine. This inhibition may represent a mechanism whereby morphine-like drugs exert their analgesic or other effects.

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Authors and Affiliations

  1. Miles Laboratories Limited, Stoke Poges, Slough, SL2, 4LY, Buckinghamshire

    H. O. J. Collier & A. C. Roy

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  1. H. O. J. Collier
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  2. A. C. Roy
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Collier, H., Roy, A. Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate. Nature 248, 24–27 (1974). https://doi.org/10.1038/248024a0

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