Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Dual Action of Praseodymium (Pr3+) on Transmitter Release at the Frog Neuromuscular Synapse

Abstract

THE release of transmitter after a nerve action potential seems to require the entry of calcium ions through the presynaptic membrane1,2. Mitochondrial uptake within the nerve terminal constitutes a possible way of removing these calcium ions temporarily3,4. While inhibition of the first process, namely the entry of calcium, would be expected to decrease the mean number of quanta liberated by a nerve impulse (quantal content, m), selective inhibition of the second process would tend to augment the release of transmitter.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Katz, B., and Miledi, R., J. Physiol., 203, 459 (1969).

    Article  CAS  Google Scholar 

  2. Katz, B., and Miledi, R., J. Physiol., 207, 789 (1970).

    Article  CAS  Google Scholar 

  3. Lehninger, A. L., Biochem. J., 119, 129 (1970).

    Article  CAS  Google Scholar 

  4. Rahamimoff, R., and Alnaes, E., Proc. natn. Acad. Sci. U.S.A., 70, 3613 (1973).

    Article  ADS  CAS  Google Scholar 

  5. Mela, L., Biochemistry, 8, 2481 (1969).

    Article  CAS  Google Scholar 

  6. Miledi, R., Nature, 229, 410 (1971).

    Article  ADS  CAS  Google Scholar 

  7. Baker, P. F., Meves, H., and Ridgway, E. B., J. Physiol., 231, 511 (1972).

    Article  Google Scholar 

  8. Heuser, J. E., and Miledi, R., Proc. R. Soc., B, 179, 247 (1971).

    ADS  CAS  Google Scholar 

  9. De Bassio, W. A., Schnitzler, R. M., and Parsons, R. L., J. Neurobiol., 2, 263 (1971).

    Article  CAS  Google Scholar 

  10. Singer, N., Krishnan, N., and Fyle, D. A., Anat. Rec., 173, 375 (1972).

    Article  CAS  Google Scholar 

  11. Heuser, J. E., and Reese, T. S., J. Cell Biol., 57, 315 (1973).

    Article  CAS  Google Scholar 

  12. Ceccarelli, B., Hurlbut, W. P., and Mauro, A., J. Cell Biol., 57, 499 (1973).

    Article  CAS  Google Scholar 

  13. Miledi, R., Proc. R. Soc., B, 183, 421 (1973).

    ADS  CAS  Google Scholar 

  14. Glagoleva, I. M., Liberman, Y. A., and Khashayev, K. M., Biofizika, 15, 76 (1970).

    CAS  PubMed  Google Scholar 

  15. Takata, M., Pickard, W. F., Lettvin, J. Y., and Moore, J. W., J. gen. Physiol., 50, 461 (1966).

    Article  CAS  Google Scholar 

  16. Blaustein, M. P., and Goldman, D. E., J. gen. Physiol., 51, 279 (1968).

    Article  CAS  Google Scholar 

  17. Manalis, R. S., and Cooper, G. P., Nature, 243, 354 (1973).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

ALNAES, E., RAHAMIMOFF, R. Dual Action of Praseodymium (Pr3+) on Transmitter Release at the Frog Neuromuscular Synapse. Nature 247, 478–479 (1974). https://doi.org/10.1038/247478a0

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/247478a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing