Abstract
IMMUNE complexes contribute to tissue damage in a variety of experimental and human diseases. Immune complexes induce arthritis1 and nephritis2,3 in laboratory animals while lupus glomerulonephritis4 and possibly rheumatoid arthritis5 are examples of their effects in man. The mechanisms by which damage is initiated and perpetuated are poorly understood. In the acute stage of inflammation resulting from immune complexes many granulocytes are present. These cells have abundant lysosomes rich in acid hydrolases which when released can degrade various tissue components. Enzyme release may result from cell death or exocytosis of granules from viable cells. Henson6 and others7,8 have shown that granulocytes exposed to immune complexes in vitro release lysosomal enzymes while remaining viable, and presumably the same happens in Arthus reactions in vivo.
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CARDELLA, C., DAVIES, P. & ALLISON, A. Immune Complexes induce Selective Release of Lysosomal Hydrolases from Macrophages. Nature 247, 46–48 (1974). https://doi.org/10.1038/247046a0
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DOI: https://doi.org/10.1038/247046a0
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