Abstract
GONADOTROPHIN treatment affects follicular maturation and induces ovulation in immature and mature mammalian females. This procedure has been used for experimental research1–8 as well as for clinical treatment in human anovulatory disease. Side effects reported when hormonally induced ovulation is followed by pregnancy include: frequent resorptions, spontaneous abortions with chromosomal anomalies, extrauterine and multiple pregnancies and difficulties in giving birth9–16.
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References
Rowlands, I. W., J. Endocr., 3, 384 (1944).
Runner, M. N., and Palm, J., J. expl. Zool., 124, 303 (1953).
Lamond, D. R., J. Endocr., 20, 277 (1960).
Wilson, E. D., and Zarrow, M. X., J. Reprod. Fert., 3, 148 (1962).
Katzberg, A. A., and Hendrickx, A. G., Science, N.Y., 152, 1225 (1966).
De La Lastra, M., Forcelledo, M. L., and Serrano, C., J. Reprod. Fert., 31, 23 (1972).
Edwards, R. G., and Gates, A. H., J. Endocr., 18, 292 (1959).
Edwards, R. G., and Fowler, R. E., J. Endocr., 21, 147 (1960).
Gibson, E. W., Jaffe, S. C., Lasley, J. F., and Day, B. N., J. Anim. Sci., 22, 858 (1963).
Fowler, R. E., and Edwards, R. G., J. Endocr., 15, 374 (1957).
Chrétien, F. C., Ann. Endocrinol., 33, 507 (1972).
Gemzell, C. A., Diczfalusy, E., and Tillinger, G., J. Endocr., 18, 1333 (1958).
Apostolakis, M., Bettendorf, G., and Voigt, K. D., Acta endocr., 41, 14 (1962).
Crooke, A. C., Br. med. Bull., 26, 17 (1970).
Berger, M. J., Taymor, M. L., Karam, K., and Nudemberg, F., Fertil. Steril., 23, 783 (1972).
Robertson, S., and Grant, A., Aust. N.Z. J. Obstet. Gynaec., 12, 253 (1972).
Boué, J. G., and Boué, A., Lancet, i, 679 (1973).
Layton, W. M., and Hallesy, D. W., Science, N.Y., 149, 306 (1965).
Vickers, T. H., Br. J. expl. Path., 53, 5 (1972).
Kleinebrecht, J., Degenhardt, K. H., Fränz, J., and Schneider, G., Teratology, 5, 295 (1972).
Grüneberg, H., The Pathology of Development (Blackwell, Oxford, 1963).
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ELBLING, L. Does Gonadotrpphin-induced Ovulation in Mice cause Malformations in the Offspring?. Nature 246, 37–39 (1973). https://doi.org/10.1038/246037a0
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DOI: https://doi.org/10.1038/246037a0
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