Abstract
THE ability of mouse liver to convert mouse or bovine albumin to a faster migrating band under acid conditions of electrophoresis has recently been found to be controlled by a dominant gene, as observed in the SWR/J and several other strains of mice1. Other strains, such as C3H/HeJ, had the recessive allele and were unable to convert albumin. The conditions used included a pH at which conformational changes in albumin are known to occur, suggesting that the strains of mice differ in a factor in the liver capable of converting albumin to a different conformational state. I report here evidence that the conversion of albumin can be reversed by lowering the pH markedly. This provides further evidence that a conformational change has taken place.
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Sogami, M., and Foster, J. F., J. biol. Chem., 237, 2514 (1962).
Petras, M. L., Biochem. Genet., 7, 273 (1972).
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WILCOX, F. Genetic Differences in Conformational Changes of Albumin in the House Mouse. Nature 246, 35 (1973). https://doi.org/10.1038/246035a0
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DOI: https://doi.org/10.1038/246035a0
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