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Emergence of Rifampin-resistance in Chlamydia trachomatis

Nature volume 244, pages 173–174 (1973)Cite this article

Abstract

RIFAMPIN exerts marked antibacterial action through the inhibition of DNA-dependent RNA polymerase. Rifampin is used clinically in treatment of tuberculosis, meningo-coccal carrier states, and some other bacterial infections. In all types of bacteria examined, the incidence of rifampin-resistant mutants was high1,2. Thus the wisdom of using rifampin as the sole drug in a chronic infection where protracted treatment might be required for cliincal cure has been questioned.

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Authors and Affiliations

  1. Department of Microbiology, University of California Medical Center, San Francisco, California, 94143

    H. KESHISHYAN, L. HANNA & E. JAWETZ

Authors
  1. H. KESHISHYAN
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  2. L. HANNA
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  3. E. JAWETZ
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KESHISHYAN, H., HANNA, L. & JAWETZ, E. Emergence of Rifampin-resistance in Chlamydia trachomatis. Nature 244, 173–174 (1973). https://doi.org/10.1038/244173a0

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