Abstract
IT is known that the metabolism of the non-histone, acidic proteins associated with DNA in the chromatin of animal cells is influenced by steroid hormones. The effects are often highly specific; for example, the administration of hydrocortisone to adrenalectomized rats leads to a selective stimulation of synthesis of a liver chromosomal protein of molecular weight 41,0001. Hydrocortisone also alters the pattern of phosphorylation of chromosomal proteins in the liver, differential effects becoming evident within minutes after injection of the hormone2,3. Similar specific alterations in the synthesis or phosphorylation of nuclear proteins have been observed in uterine cells responding to oestrogens4, in kidney cells following aldosterone administration (C. Liew, personal communication), in prostate cells stimulated by androgens5, and in insect chromosomes stimulated by ecdysone6. In all these cases, the steroid hormone also affects the RNA synthetic capacity of the target cells, presumably as a result of altered template capacity of the modified chromatin.
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ENEA, V., ALLFREY, V. Selective Synthesis of Liver Nuclear Acidic Proteins following Glucagon Administration in vivo. Nature 242, 265–267 (1973). https://doi.org/10.1038/242265b0
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DOI: https://doi.org/10.1038/242265b0
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