Abstract
The transformation of normal hematopoietic cells to leukemic cells requires cells to acquire two intrinsic changes. These are the acquisition by some method of autocrine growth stimulation and a perturbation of differentiation commitment leading to abnormal levels of self-generation. Hematopoietic regulator action can be involved to produce or facilitate both these changes but the same regulators can also suppress some leukemic populations by enforced differentiation commitment.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Author information
Authors and Affiliations
Additional information
This manuscript is based on the Charlotte Friend Memorial Lecture delivered by Professor D Metcalf at the XIX Symposium of the International Association for Comparative Research on Leukemia and Related Diseases, held in Mannheim on 12–18 July 1997. This paper also appeared in Leukemia 1997, 11: 1599–1604
Rights and permissions
About this article
Cite this article
Metcalf, D. The Charlotte Friend Memorial Lecture. The role of hematopoietic growth factors in the development and suppression of myeloid leukemias. Leukemia 13 (Suppl 1), S8–S13 (1999). https://doi.org/10.1038/sj.leu.2401376
Published:
Issue Date:
DOI: https://doi.org/10.1038/sj.leu.2401376