Abstract
AN important variant of leukaemia in man is the myelomonocytic form1, the exact nature of which is still unclear, for the only available model for studies of this disease is the mouse2. We have developed a canine model which shows promise for studies of certain aspects of the pathogenesis of myelomonocytic leukaemia (MML) as related to changes that develop in a single animal. Because dogs live longer and are larger than mice, they are well suited to serial samplings of blood, bone marrow and other tissues, facilitating dynamic studies of changes in the haematopoietic system occurring with time.
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SHIFRINE, M., BULGIN, M., DOLLARHIDE, N. et al. Transplantation of Radiation-induced Canine Myelomonocytic Leukaemia. Nature 232, 405–406 (1971). https://doi.org/10.1038/232405a0
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DOI: https://doi.org/10.1038/232405a0
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