Abstract
IN OsO4-fixed ultrathin sections of the costo-chondral junctions of 1 month old guinea-pigs, Bonucci1–3 has found osmiophilic bodies with mean diameters of 500–2,500 Å. The bodies are non-collagenous and contrast sharply with the surrounding matrix. He regarded them as the first sites of apatite nucleation, the formation of the dark needle-like crystals in the developing matrix.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bonucci, E., J. Ultrastruct. Res., 20, 33 (1967).
Bonucci, E., Calcified Tissue Res., 3, 38 (1969).
Bonucci, E., Z. Zellforschung, 103, 192 (1970).
Duncumb, P., in The Electron Microprobe (edit. by McKinley, T. D., Heinrich, K. F. J., and Wittry, D. B.), 490 (Wiley, New York, 1966).
Marshall, D. J., and Hall, T. A., Brit. J. Appl. Phys., 1, 1651 (1968).
Hall, T. A., and Höhling, H. J., in X-ray Optics and Microanalysis (edit. by Möllenstedt, G., and Gaukler, K. H.), 582 (Springer, Heidelberg, 1969).
Hall, T. A., in Physical Techniques in Biological Research I A, second ed. (edit. by Oster, G.) (Academic Press, New York, 1971).
Palade, G. E., J. Exp. Med., 95, 285 (1952).
Stäubli, W., J. Cell Biol., 16, 197 (1963).
Höhling, H. J., Hall, T. A., Boyde, A., and von Rosenstiel, A. P., Calcified Tissue Res., 2, Suppl. paper 5 (1968).
Höhling, H. J., Schopfer, H., Höhling, R. A., Hall, T. A., and Gieseking, R., Naturwissenschaften, 57, 357 (1970).
Höhling, H. J., Hall, T. A., Boothroyd, B., Cooke, C. J., Duncumb, P., Fearnhead, R. W., and Fitton-Jackson, S., in Les Tissues Calcifiés (edit. by Milhaud, G., Owen, M., and Black-wood, H. J. J.), 323 (Société d'Éidition d'Enseignement Supérieur, Paris, 1968).
Carlisle, E. M., Science, 167, 279 (1970).
Tipton, I. H., and Cook, M. J., Health Phys., 9, 103 (1963).
Urist, M. R., Clinical Orthopaedics, 44, 13 (1966).
Höhling, H. J., Hall, T. A., Boothroyd, B., Cooke, C. J., Duncumb, P., and Fitton-Jackson, S., Naturwissenschaften, 54, 142 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HALL, T., HÖHLING, H. & BONUCCI, E. Electron Probe X-Ray Analysis of Osmiophilic Globules as Possible Sites of Early Mineralization in Cartilage. Nature 231, 535–536 (1971). https://doi.org/10.1038/231535a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/231535a0
This article is cited by
-
Ultrastructural observations on the calcification of human dental pulp
Calcified Tissue Research (1973)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
