Abstract
Malignant cell transformation and its reversion are controlled by the balance between two types of chromosomes that determine the expression of malignancy or its suppression. The chromosome groups that contain these types of chromosomes have been identified.
This is a preview of subscription content, access via your institution
Access options
Similar content being viewed by others
References
Rabinowitz, Z., and Sachs, L., Nature, 220, 1203 (1968).
Rabinowitz, Z., and Sachs, L., Virology, 38, 343 (1969); ibid., 40, 193 (1970); Intern. J. Cancer, 6, 388 (1970); Inbar, M., Rabinowitz, Z., and Sachs, L., Intern. J. Cancer, 4, 690 (1969).
Rabinowitz, Z., and Sachs, L., Nature, 225, 136 (1970).
Pollack, R., Green, H., and Todaro, G., Proc. US Nat. Acad. Sci., 60, 126 (1968).
Ossovski, L., and Sachs, L., Proc. US Nat. Acad. Sci., 58, 1938 (1967).
Inbar, M., and Sachs, L., Proc. US Nat. Acad. Sci., 63, 1418 (1969); Nature, 223, 710 (1969); Ben-Bassat, H., Inbar, M., and Sachs, L., Virology, 40, 854 (1970); Shoham, J., Inbar, M., and Sachs, L., Nature, 227, 1244 (1970); Sela, B., Lis, H., Sharon, N., and Sachs, L., J. Membrane Biol., 3, 267 (1970).
Pollack, R., Wolman, S., and Vogel, A., Nature, 228, 938 (1970).
Sachs, L., Heredity, 6, 357 (1952).
Lehman, J. M., MacPherson, I., and Moorhead, P. S., J. Nat. Cancer Inst., 31, 639 (1963).
Huberman, E., Salzberg, S., and Sachs, L., Proc. US Nat. Acad. Sci., 59, 77 (1968); Huberman, E., and Sachs, L., J. Nat. Cancer Inst., 40, 329 (1968).
Weiss, M. C., Todaro, G. J., and Green, H., J. Cell Physiol., 71, 105 (1968).
Harris, H., Miller, O. J., Klein, G., Worst, P., and Tachibana, T., Nature, 223, 363 (1969).
Puck, T. T., and Kao, F., Proc. US Nat. Acad. Sci., 58, 1227 (1967).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HITOTSUMACHI, S., RABINOWITZ, Z. & SACHS, L. Chromosomal Control of Reversion in Transformed Cells. Nature 231, 511–514 (1971). https://doi.org/10.1038/231511a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/231511a0
This article is cited by
-
Cell differentiation and malignancy
Cell Biophysics (1986)
-
Hematopoietic growth and differentiation factors and the reversibility of malignancy: Cell differentiation and by-passing of genetic defects in leukemia
Medical Oncology and Tumor Pharmacotherapy (1986)
-
Characterization of a stable, anchorage-dependent clone obtained from a spontaneously transformed mouse cell line
In Vitro (1984)
-
Suppression of malignancy in human cells
Nature (1976)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.