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Enhancement of Metastases by L-Asparaginase in a Mouse Tumour System

Nature volume 231, pages 319–321 (1971)Cite this article

Abstract

IT has been reported that the new antileukaemic and antitumour agent, L-asparaginase, has significant immunosuppressive activity1–6. We have studied the effect of L-asparaginase on the mouse tumour sarcoma 180 grown as a foot implant, which metastasizes only rarely to the regional popliteal node, but metastasizes extensively after the host has been treated with an immunosuppressive agent such as antilymphocyte serum7. There was a striking enhancement of metastases when the mice were treated with L-asparaginase even in doses considerably smaller than those used by previous investigators which had no antitumour effect.

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Authors and Affiliations

  1. Department of Immunology, Divisions of Research and Laboratory Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, 44106

    SHARAD D. DEODHAR

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  1. SHARAD D. DEODHAR
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DEODHAR, S. Enhancement of Metastases by L-Asparaginase in a Mouse Tumour System. Nature 231, 319–321 (1971). https://doi.org/10.1038/231319a0

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  • DOI: https://doi.org/10.1038/231319a0

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