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Drug Receptors and their Function

Abstract

There have been various theories about the way in which drugs exert their effects. If recent progress in the isolation of receptors continues, it should soon be possible to look directly at the interaction between drugs and tissues.

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References

  1. Langley, J. N., J. Physiol., 33, 374 (1905).

    Article  Google Scholar 

  2. Hill, A. V., J. Physiol., 39, 361 (1909).

    Article  CAS  Google Scholar 

  3. Clark, A. J., Mode of Action of Drugs on Cells (Arnold, London, 1933).

    Google Scholar 

  4. Clark, A. J., Handbuch der Experimentellen Pharmakologie, 4 (1937).

  5. Furchgott, R. F., Pharm. Rev., 7, 183 (1955).

    CAS  Google Scholar 

  6. Furchgott, R. F., Ann. Rev. Pharmacol., 4, 21 (1964).

    Article  CAS  Google Scholar 

  7. Ariens, E. J., (ed.), Molecular Pharmacology, 1 (Academic Press, London and New York, 1964).

  8. Gill, E. W., Prog. Med. Chem., 4, 39 (1965).

    Article  CAS  Google Scholar 

  9. Burgen, A. S. V., J. Pharm. Pharmacol., 18, 137 (1966).

    Article  CAS  Google Scholar 

  10. Waud, D. R., Pharm. Rev., 20, 49 (1968).

    CAS  PubMed  Google Scholar 

  11. Ehrenpreis, S., Fleisch, J. H., and Mittag, T. W., Pharm. Rev., 21, 131 (1969).

    CAS  PubMed  Google Scholar 

  12. Symp. Drug Antagonism. Pharm. Rev., 9, 211 (1957).

  13. Adv. Drug Res., 2 (1965); ibid., 3 (1966).

  14. Symp. Cholinergic Mechanisms. Ann. NY Acad. Sci., 144 (1967).

  15. Fundamental Concepts in Drug-Receptor Interactions (edit. by Danielli, J. F., Moran, J. F., and Triggle, D. J.) (Academic Press, London and New York, 1970).

  16. Molecular Properties of Drug Receptors (edit. by Porter, R., and O'Connor, M.), Ciba Foundation Symposium (Churchill, London, 1970).

  17. Takeuchi, A., and Takeuchi, N., J. Physiol., 205, 377 (1969).

    Article  CAS  Google Scholar 

  18. Monod, J., Changeux, J. P., and Jacob, J., J. Mol. Biol., 6, 306 (1963).

    Article  CAS  Google Scholar 

  19. Monod, J., Wyman, J., and Changeux, J. P., J. Mol. Biol., 12, 88 (1965).

    Article  CAS  Google Scholar 

  20. Wyman, J., Quart. Rev. Biophys., 1, 35 (1968).

    Article  CAS  Google Scholar 

  21. Changeux, J. P., Thiéry, J., Tung, Y., and Kittel, C., Proc. US Nat. Acad. Sci., 57, 335 (1967).

    Article  ADS  CAS  Google Scholar 

  22. Karlin, A., J. Theoret. Biol., 16, 306 (1967).

    Article  CAS  Google Scholar 

  23. Ginsborg, B. L., Pharm. Rev., 19, 289 (1967).

    CAS  PubMed  Google Scholar 

  24. Hodgkin, A. L., and Horowicz, P., J. Physiol., 153, 386 (1960).

    Article  CAS  Google Scholar 

  25. Heistracher, P., and Hunt, C. C., J. Physiol., 201, 589 (1969).

    Article  CAS  Google Scholar 

  26. Nickerson, M., Nature, 178, 697 (1956).

    Article  ADS  CAS  Google Scholar 

  27. Stephenson, R. P., Brit. J. Pharmacol. Chemother., 11, 379 (1956).

    Article  CAS  Google Scholar 

  28. Furchgott, R. F., and Bursztyn, P., Ann. NY Acad. Sci., 144, 882 (1967).

    Article  ADS  CAS  Google Scholar 

  29. van Rossum, J. M., Adv. Drug. Res., 3, 189 (1966).

    Google Scholar 

  30. Rang, H. P., Proc. Roy. Soc., B, 164, 488 (1966).

    Article  ADS  CAS  Google Scholar 

  31. Schild, H. O., Brit. J. Pharmacol. Chemother., 2, 189 (1947).

    Article  CAS  Google Scholar 

  32. Arunlakshana, O., and Schild, H. O., Brit. J. Pharmacol. Chemother., 14, 48 (1959).

    Article  CAS  Google Scholar 

  33. Jenkinson, D. H., J. Physiol., 152, 309 (1960).

    Article  CAS  Google Scholar 

  34. Lullman, H., Ohnesorge, F. K., Schauwecker, G.-C., and Wassermann, O., Europ. J. Pharmacol., 6, 241 (1969).

    Article  Google Scholar 

  35. Ariens, E. J., Arch. Intern. Pharmacodyn., 99, 32 (1954).

    CAS  Google Scholar 

  36. Manalis, R. S., and Werman, R., Physiologist, 12, 292 (1969).

    Google Scholar 

  37. Koester, J., and Nastuk, W. L., Fed. Proc., 290, 716 (1970).

    Google Scholar 

  38. Katz, B., and Miledi, R., Nature, 226, 962 (1970).

    Article  ADS  CAS  Google Scholar 

  39. Paton, W. D. M., Proc. Roy. Soc., B, 154, 21 (1961).

    Article  ADS  Google Scholar 

  40. Paton, W. D. M., and Rang, H. P., Adv. Drug. Res., 3, 57 (1966).

    Google Scholar 

  41. Bellau, B., J. Med. Chem., 7, 776 (1964).

    Article  Google Scholar 

  42. Changeux, J. P., and Podleski, T., Proc. US Nat. Acad. Sci., 59, 944 (1968).

    Article  ADS  CAS  Google Scholar 

  43. Katz, B., and Thesleff, S., J. Physiol., 138, 63 (1957).

    Article  CAS  Google Scholar 

  44. Werman, R., and Brookes, N., Fed. Proc., 28, 831 (1969).

    Google Scholar 

  45. Karlin, A., Proc. US Nat. Acad. Sci., 58, 1162 (1967).

    Article  ADS  CAS  Google Scholar 

  46. Podleski, T., and Changeux, J.-P., in Fundamental Concepts in Drug-Receptor Interactions (Academic Press, London and New York, 1970).

    Google Scholar 

  47. Koshland, D. E., and Neet, K. E., Ann. Rev. Biochem., 37, 359 (1968).

    Article  CAS  Google Scholar 

  48. Koshland, D. E., Némethy, G., and Filmer, D., Biochemistry, 5, 365 (1966).

    Article  CAS  Google Scholar 

  49. Eigen, M., Quart. Rev. Biophys., 1, 3 (1968).

    Article  CAS  Google Scholar 

  50. Clark, A. J., J. Physiol., 61, 530 (1926).

    Article  CAS  Google Scholar 

  51. Miller, J. W., and Lewis, J. E., Ann. Rev. Pharmacol., 9, 147 (1968).

    Article  Google Scholar 

  52. Chagas, C., Ann. NY Acad. Sci., 81, 345 (1959).

    Article  ADS  CAS  Google Scholar 

  53. Ehrenpreis, S., Proc. First Intern. Pharm. Meeting, 7, 119 (1963).

    CAS  Google Scholar 

  54. Paton, W. D. M., and Rang, H. P., Proc. Roy. Soc., B, 163, 1 (1965).

    Article  ADS  CAS  Google Scholar 

  55. Thron, D., and Waud, D. R., J. Pharmacol., 160, 91 (1968).

    CAS  Google Scholar 

  56. Potter, L. T., J. Pharmacol., 155, 91 (1967).

    CAS  Google Scholar 

  57. O'Brien, R. D., and Gilmour, L. P., Proc. US Nat. Acad. Sci., 63, 496 (1969).

    Article  ADS  CAS  Google Scholar 

  58. O'Brien, R. P., Gilmour, L. P., and Eldefrawi, M. E., Proc. US Nat. Acad. Sci., 65, 438 (1970).

    Article  ADS  CAS  Google Scholar 

  59. Singer, S. J., Adv. Prot. Chem., 22, 1 (1967).

    CAS  Google Scholar 

  60. Baker, B. R., Design of Active Site Directed Irreversible Enzyme Inhibitors (Wiley, New York, 1968).

    Google Scholar 

  61. Lewis, J. E., and Miller, J. W., J. Pharmacol., 154, 46 (1966).

    CAS  Google Scholar 

  62. Takagi, K., and Takahashi, A., Biochem. Pharmacol., 17, 1609 (1968).

    Article  CAS  Google Scholar 

  63. Karlin, A., Prives, J., Deal, W., and Winnick, M., in Molecular Properties of Drug Receptors, 247 (Churchill, London, 1970).

    Google Scholar 

  64. Karlin, A., and Winnick, M., Proc. US Nat. Acad. Sci., 60, 668 (1968).

    Article  ADS  CAS  Google Scholar 

  65. Gill, E. W., and Rang, H. P., Mol. Pharmacol., 2, 284 (1966).

    CAS  PubMed  Google Scholar 

  66. Rang, H. P., Ann. NY Acad. Sci., 144, 756 (1967).

    Article  ADS  CAS  Google Scholar 

  67. Rang, H. P., and Ritter, J. M., Mol. Pharmacol., 5, 394 (1969).

    CAS  PubMed  Google Scholar 

  68. Rang, H. P., and Ritter, J. M., Mol. Pharmacol., 6, 383 (1970).

    CAS  PubMed  Google Scholar 

  69. Rang, H. P., and Ritter, J. M., Mol. Pharmacol., 6, 357 (1970).

    CAS  PubMed  Google Scholar 

  70. Chang, C. C., and Lee, C. Y., Arch. Intern. Pharmacodyn., 144, 241 (1963).

    CAS  Google Scholar 

  71. Lee, C. Y., and Tseng, L. F., Toxicon, 3, 281 (1966).

    Article  CAS  Google Scholar 

  72. Changeux, J. P., Kasai, M., and Lee, C. Y., Proc. US Nat. Acad. Sci., 67, 1241 (1970).

    Article  ADS  CAS  Google Scholar 

  73. Miledi, R., Molinoff, P., and Potter, L., Nature, 229, 554 (1971).

    Article  ADS  CAS  Google Scholar 

  74. Hokin, L. E., in Fundamental Concepts in Drug-Receptor Interactions, 205 (Academic Press, London and New York, 1970).

    Google Scholar 

  75. Flacke, W., and Yeoh, T. S., Brit. J. Pharmacol., 33, 145 (1968).

    CAS  PubMed  Google Scholar 

  76. Gaddum, J. H., J. Physiol., 61, 141 (1926).

    Article  CAS  Google Scholar 

  77. Blinks, J. R., Ann. NY Acad. Sci., 139, 673 (1967).

    Article  ADS  CAS  Google Scholar 

Download references

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RANG, H. Drug Receptors and their Function. Nature 231, 91–96 (1971). https://doi.org/10.1038/231091a0

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