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Water in Biological Systems

Abstract

The object of this article is to draw attention to some of the major areas of investigation of the state of water in biochemical and biological systems. Deductions about the role of water in such systems are somewhat speculative, but the situation might be improved.

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References

  1. Klotz, I., Brookhaven Symp. Biol., 13, 25 (1960).

    CAS  Google Scholar 

  2. Kauzmann, W., Adv. Protein Chem., 14, 1 (1959).

    Article  CAS  Google Scholar 

  3. Kendrew, J. C., Brookhaven Symp. Biol., 15, 216 (1962).

    CAS  Google Scholar 

  4. Cullis, A. F., Muirhead, H., Perutz, M. F., Rosman, M. G., and North, A. C. T., Proc. Roy. Soc., A, 265, 161 (1962).

    Article  ADS  CAS  Google Scholar 

  5. Frank, H. S., and Evans, M. W., J. Chem. Phys., 13, 507 (1945).

    Article  ADS  CAS  Google Scholar 

  6. Franks, F., Hydrogen Bonded Solvent Systems (edit. by Covington, A. K., and Jones, P.), 30 (Taylor and Francis, London, 1968).

    Google Scholar 

  7. Scheraga, H. A., Ber. Bunseng., 68, 838 (1964).

    Article  CAS  Google Scholar 

  8. Del Bene, J., and Pople, J. A., J. Chem. Phys., 52, 4858 (1970).

    Article  ADS  CAS  Google Scholar 

  9. Franks, F., and Smith, H. T., Trans. Faraday Soc., 64, 2962 (1968).

    Article  CAS  Google Scholar 

  10. Ling, G. N., A Physical Theory of the Living State, xxviii (Blaisdell, New York, 1962).

    Google Scholar 

  11. Bhattacharya, Bhandarkar, M. K., and Gaur, B. K., Physiol. Plant., 22, 1025 (1969).

    Article  CAS  Google Scholar 

  12. Bender, M. L., and Hamilton, G. A., J. Amer. Chem. Soc., 84, 2570 (1962).

    Article  CAS  Google Scholar 

  13. Long, F. A., and Bigeleisin, J., Trans. Faraday Soc., 55, 2077 (1959).

    Article  CAS  Google Scholar 

  14. Henderson, R. F., and Henderson, T. R., Arch. Biochem. Biophys., 129, 86 (1969).

    Article  CAS  Google Scholar 

  15. Bratton, C. B., Hopkins, A. L., and Weinburg, J. W., Science, 147, 738 (1965).

    Article  ADS  CAS  Google Scholar 

  16. Hazlewood, C. F., Nichols, B. L., and Chamberlain, N. F., Nature, 222, 747 (1969).

    Article  ADS  CAS  Google Scholar 

  17. Cope, F. W., Biophys. J., 9, 303 (1969).

    Article  ADS  CAS  Google Scholar 

  18. Clifford, J., and Sheard, B., Biopolymers, 4, 1057 (1966).

    Article  CAS  Google Scholar 

  19. Maeda, Y., Fujita, T., Suguira, Y., and Koga, S., J. Gen. Appl. Microbiol., 14, 217 (1968).

    Article  CAS  Google Scholar 

  20. Fedotov, V. D., Miftakhutdinova, F. G., and Murtazin, S. F., Biophysics, 14, 918 (1969).

    Google Scholar 

  21. Berendsen, H. J. C., Biology of the Mouth, 145 (1968).

    Google Scholar 

  22. Dehl, R. E., and Hoeve, C. A., J. Chem. Phys., 50, 3245 (1969).

    Article  ADS  CAS  Google Scholar 

  23. Migchelsen, C., Berendsen, H. J. C., and Rupprecht, A., J. Mol. Biol., 37, 235 (1968).

    Article  CAS  Google Scholar 

  24. Child, T. F., Pryce, N. G., Tait, M. J., and Ablett, S., Chem. Commun., 1214 (1970).

  25. Rees, D. A., Adv. Carbohydrate Chem., 24, 267 (1969).

    CAS  Google Scholar 

  26. Glasel, J. A., J. Amer. Chem. Soc., 92, 375 (1970).

    Article  CAS  Google Scholar 

  27. Woessner, D. E., and Snowdon, B. S., J. Colloid Interface Sci., 34, 290 (1970).

    Article  ADS  CAS  Google Scholar 

  28. Warner, D. T., Ann. NY Acad. Sci., 125, 605 (1965).

    Article  ADS  CAS  Google Scholar 

  29. Hechter, O., Ann. NY Acad. Sci., 125, 625 (1965).

    Article  ADS  CAS  Google Scholar 

  30. Douglas, D. C., Frisch, H. L., and Anderson, E. O., Biochim. Biophys. Acta, 44, 401 (1960).

    Article  CAS  Google Scholar 

  31. Drost-Hansen, W., Ind. Eng. Chem., 10 (1969).

  32. Glew, D. N., Mak, H. D., and Rath, N. S., Hydrogen-Bonded Solvent Systems (edit. by Covington, A. K., and Jones, P.) (Taylor and Francis, London, 1968).

    Google Scholar 

  33. Feil, D., and Jeffrey, G. A., J. Chem. Phys., 35, 1863 (1961).

    Article  ADS  CAS  Google Scholar 

  34. Berendsen, H. J. C., and Migchelsen, C., Ann. NY Acad. Sci., 125, 365 (1965).

    Article  ADS  CAS  Google Scholar 

  35. Berendsen, H. J. C., J. Chem. Phys., 36, 3297 (1962).

    Article  ADS  CAS  Google Scholar 

  36. Deryagin, B. V., Talaev, M. V., and Fedyakin, N. N., Dokl. Akad. Nauk SSSR, 165, 597 (1965); translation in Proc. Acad. Sci., USSR Phys. Chem., 165, 807 (1965).

    Google Scholar 

  37. Lippincott, E. R., Stromberg, R. R., Grant, W. H., and Cessac, G. L., Science, 164, 1482 (1969).

    Article  ADS  CAS  Google Scholar 

  38. Franks, F., Chemistry and Industry, 560 (1968).

    Google Scholar 

  39. Hertz, H. G., and Klute, R., Z. Phys. Chem., 69, 101 (1970).

    Article  CAS  Google Scholar 

  40. Klotz, I. M., Horizons in Biochemistry (Academic Press, New York, 1962).

    Google Scholar 

  41. Chapman, G. E., and McLauchlan, K. A., Proc Roy. Soc., B, 173, 223 (1969).

    Article  ADS  CAS  Google Scholar 

  42. Shereshefsky, J. L., and Folman, M., J. Phys. Chem., 59, 607 (1955).

    Article  Google Scholar 

  43. Privalov, P. L., Water in Biological Systems (edit. by Kayushin, L. P.) (Consultants Bureau, New York, 1969).

    Google Scholar 

  44. Klotz, I. M., Fed. Proc., 24, 5 (1965).

    Google Scholar 

  45. von Hippel, P., Structure and Stability of Biological Macromolecules, 2 (edit. by Timashef, S., and Fasman, G.) (Dekker, New York, 1969).

    Google Scholar 

  46. Blake, C. C. F., Koenig, D. F., Mzir, G. A., North, A. C. T., Phillips, D. C., and Sarma, V. R., Nature, 206, 757 (1965).

    Article  ADS  CAS  Google Scholar 

  47. Wright, C. S., Alden, R. A., and Kraut, J., Nature, 221, 235 (1969).

    Article  ADS  CAS  Google Scholar 

  48. Alfsen, A., Baulieu, E. E., Claquin, M. J., and Falcoz-Kelly, F., Excerpta Medica Intern. Cong., 132, 508 (1966).

    Google Scholar 

  49. Royer, G. P., and Klotz, I. M., J. Amer. Chem. Soc., 91, 5885 (1969).

    Article  CAS  Google Scholar 

  50. Cordes, E. H., and Jencks, W. P., J. Amer. Chem. Soc., 85, 2843 (1963).

    Article  CAS  Google Scholar 

  51. Swain, C. G., and Brown, J. F., J. Amer. Chem. Soc., 74, 2534, 2538 (1954).

    Article  Google Scholar 

  52. Krupka, R. M., and Laidler, K. J., J. Amer. Chem. Soc., 83, 1458 (1961).

    Article  CAS  Google Scholar 

  53. Ling, G. N., Ann. NY Acad. Sci., 125, 401 (1965).

    Article  ADS  CAS  Google Scholar 

  54. Ling, G. N., Food Technol., 22, 1254 (1968).

    CAS  Google Scholar 

  55. Chambers, R., and Hale, H. P., Proc. Roy. Soc., B, 110, 336 (1932).

    Article  ADS  CAS  Google Scholar 

  56. Cope, F. W., J. Gen. Physiol., 50, 1353 (1966).

    Article  Google Scholar 

  57. Ling, G. N., and Cope, F. W., Science, 163, 1335 (1969).

    Article  ADS  CAS  Google Scholar 

  58. Czeisler, J. L., Fritz, O. G., and Swift, T. L., Biophys. J., 10, 260 (1970).

    Article  ADS  CAS  Google Scholar 

  59. MacRobbie, E. A. C., Quart. Rev. Biophysics, 3, 251 (1970).

    Article  CAS  Google Scholar 

  60. Kushmerick, M. J., and Podolsky, R. J., Science, 166, 1297 (1969).

    Article  ADS  CAS  Google Scholar 

  61. Cope, F. W., Bull. Math. Biophys., 29, 583 (1967).

    Article  CAS  Google Scholar 

  62. Hechter, O., Ann. NY Acad. Sci., 125, 249 (1965).

    Google Scholar 

  63. Nature, 223, 1317 (1969).

  64. Lumry, R., Biltonen, E., and Brandts, J. F., Biopolymers, 4, 917 (1966).

    Article  CAS  Google Scholar 

  65. Tracey, M. V., Proc. Roy. Soc., B, 171, 59 (1968).

    Article  ADS  CAS  Google Scholar 

  66. Weigl, J., Z. Naturforsch., 22, B, 885 (1967).

    Article  CAS  Google Scholar 

  67. Weigl, J., Z. Naturforsch., 23, B, 1253 (1968).

    Article  CAS  Google Scholar 

  68. Berger, E. Y., Pecikyan, F. R., and Kauzaki, G., J. Gen. Physiol., 52, 876 (1969).

    Article  Google Scholar 

  69. Sabelli, H. C., and Priest, W. C., Arzneim-Forsch. (Drug Res.), 1, 80 (1970).

    Google Scholar 

  70. Fritz, G. G., and Swift, T. J., Biophys. J., 7, 675 (1967).

    Article  CAS  Google Scholar 

  71. Klotz, I. M., Ayers, J., Ho, J. Y. C., Horowitz, M. G., and Heiney, R. E., J. Amer. Chem. Soc., 82, 2132 (1958).

    Article  Google Scholar 

  72. Bradbury, E. M., and Crane-Robinson, C., Nature, 220, 1079 (1968).

    Article  ADS  CAS  Google Scholar 

  73. Fellner-Feldegg, H., J. Phys. Chem., 73, 616 (1969).

    Article  CAS  Google Scholar 

  74. Suggett, A., Mackness, P. A., Tait, M. J., Loeb, H. W., and Young, G. M., Nature, 228, 456 (1970).

    Article  ADS  CAS  Google Scholar 

  75. Hertz, H. G., Relaxation Times, Progress in NMR Spectroscopy (edit. by Elmsley, Feeney, and Sutcliffe) (Pergamon, 3, 1967).

    Google Scholar 

  76. Gent, W. L. G., Grant, E. H., and Tucker, S. W., Biopolymers, 9, 124 (1970).

    Article  CAS  Google Scholar 

  77. Arnett, E. M., and McKelvey, D. R., Solute-Solvent Interactions (edit. Coetzee, J. F., and Ritchie, C. D.), ch. 6 (Dekker, 1969).

    Google Scholar 

  78. Doherty, D., and Vaslow, F., J. Amer. Chem. Soc., 74, 931 (1952).

    Article  CAS  Google Scholar 

  79. Brandts, J., and Hunt, L., J. Amer. Chem. Soc., 89, 4826 (1967).

    Article  CAS  Google Scholar 

  80. Lumry, R., and Rajender, S., Biopolymers, 9, 1125 (1970).

    Article  CAS  Google Scholar 

  81. Sturtevant, J. M., First Intern. Conf. Calorimetry and Thermodynamics, Warsaw (September 1969).

    Google Scholar 

  82. Benzinger, T. H., Proc. US Nat. Acad. Sci., 42, 109 (1956).

    Article  ADS  CAS  Google Scholar 

  83. Eisenberg, D., and Kauzmann, W., The Structure and Properties of Water (Oxford University Press, New York, 1969).

    Google Scholar 

Download references

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TAIT, M., FRANKS, F. Water in Biological Systems. Nature 230, 91–94 (1971). https://doi.org/10.1038/230091a0

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