Abstract
THE psychotomimetic methoxyamphetamines are drugs which chemically resemble both mescaline and amphetamine. The subjective effects produced by them are similar to those elicited by other psychotomimetic agents1–3 and cross tolerance has been demonstrated between at least one methoxyamphetamine and mescaline3. There may be some differences in the actions of these drugs and other psychotomimetic agents such as D-lysergic acid diethylamide (LSD), for in clinical trials4–7 and animal tests8 some methoxyamphetamines show considerable amphetamine-like activity, and one of them can produce marked enhancement of self-awareness in the absence of perceptual distortions and disorganization of thinking4–7.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Shulgin, A. T., Sargent, T., and Naranjo, C., Nature, 221, 537 (1969).
Shulgin, A. T., in Psychotomimetic Drugs (edit. by Efron, D.), 21 (Raven Press, New York, 1970).
Snyder, S. H., Faillace, L. A., and Hollister, L., Science, 158, 669 (1970).
Snyder, S. H., Faillace, L. A., and Weingartner, H., Amer. J. Psychiat., 125, 357 (1968).
Snyder, S. H., Faillace, L. A., and Weingartner, H., Arch. Gen. Psychiat., 21, 9 (1969).
Snyder, S. H., Weingartner, H., and Faillace, L. A., Arch. Gen. Psychiat. (in the press).
Snyder, S. H., Weingartner, H., and Faillace, L. A., in Psychotomimetic Drugs (edit. by Efron, D.), 247 (Raven Press, New York, 1970).
Beaton, J. M., Smythies, J. R., Benington, F., and Morin, R. D., Comm. Behav. Biol., 3, 81 (1969).
Smythies, J. R., Johnston, V. S., Bradley, R. J., Benington, F., Morin, R. D., and Clark, L. C., Nature, 216, 128 (1967).
Uyeno, E. T., J. Pharm. Exp. Ther., 159, 216 (1968).
Uyeno, E. T., Otis, L. S., and Mitoma, C., Comm. Behav. Biol., A 1, 83 (1968).
Snyder, S. H., and Richelson, E., Proc. US Nat. Acad. Sci., 60, 206 (1968).
Snyder, S. H., and Richelson, E., in Psychotomimetic Drugs (edit. by Efron, D.), 43 (Raven Press, New York, 1970).
Hendley, E. D., Taylor, K. M., and Snyder, S. H., Europ. J. Pharmacol. (in the press).
Eisenfeld, A. J., Axelrod, J., and Krakoff, L., J. Pharm. Exp. Ther., 156, 107 (1967).
Eisenfeld, A. J., Landsberg, L., and Axelrod, J., J. Pharm. Exp. Ther., 158, 378 (1967).
Iversen, L. L., Brit. J. Pharmacol., 25, 18 (1965).
Lightman, S., and Iversen, L. L., Brit. J. Pharmacol., 37, 638 (1969).
Kalsner, S., and Nickerson, M., Brit. J. Pharmacol., 35, 440 (1969).
Simmonds, M. A., and Gillis, C. N., J. Pharm. Exp. Ther., 159, 283 (1968).
Hendley, E. D., and Snyder, S. H., Fed. Proc., 28, 674 (1969).
McIlwain, H., and Rodnight, R., Practical Neurochemistry (Little, Brown and Company, Boston, 1962).
Schweitzer, J. W., and Friedhoff, A. J., Biochem. Pharmacol., 15, 2097 (1966).
Sargent, T. W., Israelstam, D. M., Shulgin, A. T., Landow, S. A., and Finley, N. N., Biochem. Biophys. Res. Comm., 29, 126 (1967).
Ellison, T., Gutzait, L., and Van Loon, E. J., J. Pharm. Exp. Ther., 152, 383 (1966).
Phillips, G. F., and Mesley, R. J., J. Pharm. Pharmacol., 21, 9 (1969).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HENDLEY, E., SNYDER, S. Correlation between Psychotropic Potency of Psychotomimetic Methoxyamphetamines and their Inhibition of 3H-Normetanephrine Uptake in Rat Cerebral Cortex. Nature 229, 264–266 (1971). https://doi.org/10.1038/229264a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/229264a0
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
