Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Evidence for a New Haemoglobin Chain (ζ-Chain)

Abstract

THE possibility of a human embryonic haemoglobin was first indicated by the work of Drescher and Kunzer1. Two such haemoglobins, Hb-Grower 1 and Hb-Gower 2, have been discovered2,3 and their structures are ɛ4 and α2ɛ2 respectively. The ɛ-chain is a distinct haemoglobin chain synthesized during embryonic development. It has therefore been suggested4 that there is a separate genetic locus determining the structure of the ɛ-chain, just as there are separate loci determining the structure of the α, β, γ, and δ-haemoglobin chains5.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Drescher, H., and Kunzer, W., Clin. Wschr., 32, 92 (1954).

    Article  CAS  Google Scholar 

  2. Huehns, E. R., Flynn, F. V., Butler, E. A., and Beaven, G. H., Nature, 189, 496 (1961).

    Article  ADS  CAS  Google Scholar 

  3. Huehns, E. R., Dance, N., Beaven, G. H., Keil, J. V., Hecht, F., and Motulsky, A. G., Nature, 201, 1095 (1964).

    Article  ADS  CAS  Google Scholar 

  4. Huehns, E. R., Dance, N., Beaven, G. H., Hecht, F., and Motulsky, A. G., Cold Spring Harbor Symp. Quant. Biol., 29, 327 (1964).

    Article  CAS  Google Scholar 

  5. Baglioni, C., in Molecular Genetics (edit. by Taylor, J. H.), 1, 405 (Academic Press, New York, and London, 1963).

    Google Scholar 

  6. Capp, G. L., thesis (Univ. of Oregon, 1966).

  7. Capp, G. L., Rigas, D. A., and Jones, R. T., Science, 157, 65 (1967).

    Article  ADS  CAS  Google Scholar 

  8. Hecht, F., Jones, R. T., and Koler, R. D., Ann. Hum. Genet., 31, 215 (1967).

    Article  Google Scholar 

  9. Jones, R. T., Cold Spring Harbor Symp. Quant. Biol., 29, 297 (1964).

    Article  CAS  Google Scholar 

  10. Szelenyi, J. G., and Hollan, S. R., Acta Biochim. Biophys. Acad. Sci. Hung., 4, 47 (1969).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

CAPP, G., RIGAS, D. & JONES, R. Evidence for a New Haemoglobin Chain (ζ-Chain). Nature 228, 278–280 (1970). https://doi.org/10.1038/228278b0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/228278b0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing