Abstract
If RNA is synthesized on the chromatin deoxyribonucleoprotein (DNP) template, the chains formed are four to five times shorter than in RNA synthesized on a DNA template. This correlates with the decrease of the period of elongation. After the removal of histone F1 from DNP the RNA chains synthesized are as long as or longer than those formed on free DNA. Histone F1 seems to prevent the movement of RNA polymerase along the DNA.
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KOSLOV, Y., GEORGIEV, G. Mechanism of Inhibitory Action of Histones on DNA Template Activity in vitro. Nature 228, 245–247 (1970). https://doi.org/10.1038/228245a0
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DOI: https://doi.org/10.1038/228245a0
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