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Evidence for Premature Termination of Transcription of the Tryptophan Operon in Polarity Mutants of Escherichia coli

Abstract

The polarity of mutations in the tryptophan operon of E. coli may be caused not by an accelerated degradation of untranslated messenger operator–distal to the nonsense codon but by premature termination of transcription at or near the site of mutation and by restriction of RNA polymerase movement beyond it.

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IMAMOTO, F. Evidence for Premature Termination of Transcription of the Tryptophan Operon in Polarity Mutants of Escherichia coli. Nature 228, 232–235 (1970). https://doi.org/10.1038/228232a0

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