Abstract
X-ray diffraction and circular dichroism studies indicate that poly d(I–C).poly d(I–C) exists in a new polynucleotide configuration—an eight-fold helix, possibly left-handed.
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References
Grant, R. C., Harwood, S. J., and Wells, R. D., J. Amer. Chem. Soc., 90, 4474 (1968).
Wells, R. D., Larson, J. E., Grant, R. C., Shortle, B. E., and Cantor, C. R., J. Mol. Biol. (in the press).
Sundaralingam, M., Biopolymers, 7, 821 (1969).
Klug, A., Crick, F. H. C., and Wyckoff, H. W., Acta Cryst., 11, 199 (1958).
Yang, J. T., and Samejima, T., Prog. Nucleic Acid Res., 9, 223 (1969).
Tinoco, jun., I., and Cantor, C. R., Methods of Biochemical Analysis, 18, 81 (1970).
Ts'o, P. O. P., Rapaport, S. A., and Bollum, F. J., Biochemistry, 5, 4153 (1966).
Johnson, W. C., and Tinoco, jun., I., Biopolymers, 7, 727 (1969).
Yang, J. T., and Samejima, T., Biochem. Biophys. Res. Commun., 33, 739 (1968).
Sarkar, P. K., and Yang, J. T., J. Biol. Chem., 240, 2088 (1965).
Sarkar, P. K., and Yang, J. T., Biochemistry, 4, 1238 (1965).
Ward, D. C., and Reich, E., Proc. US Nat. Acad. Sci., 61, 1494 (1968).
Warshaw, M. M., and Cantor, C. R., Biopolymers, 9, 1079 (1970).
Cantor, C. R., Warshaw, M. M., and Shapiro, H., Biopolymers, 9, 1059 (1970).
Tazawa, I., Tazawa, S., Stempel, L. M., and Ts'o, P. O. P., Biochemistry, 9, 3499 (1970).
Fric, I., Guschlbauer, W., and Holy, A., FEBS Letters, 9, 261 (1970).
Cantor, C. R., Fairclough, R., and Newark, R. A., Biochemistry, 8, 3610 (1969).
Harwood, S. J., Schendel, P. F., and Wells, R. D., J. Biol. Chem., 245, 5614 (1970).
Richardson, C. C., Schildkraut, C. L., Aposhian, H. V., and Kornberg, A., J. Biol. Chem., 239, 222 (1964).
Morgan, A. R., and Wells, R. D., J. Mol. Biol., 37, 63 (1968).
Karstadt, M., and Krakow, J. S., J. Biol. Chem., 245, 746 (1970).
Richardson, C. C., Proc. US Nat. Acad. Sci., 54, 158 (1965).
Weiss, B., Jacquemin-Sablon, A., Live, T. R., Fareed, G. C., and Richardson, C. C., J. Biol. Chem., 243, 4543 (1968).
Lehman, I. R., and Nussbaum, A. L., J. Biol. Chem., 239, 2628 (1964).
Jovin, T. M., Englund, P. T., and Bertsch, L. L., J. Biol. Chem., 244, 2996 (1969).
Harwood, S. J., Schendel, P. F., Miller, L. K., and Wells, R. D., Proc. US Nat. Acad. Sci., 66, 595 (1970).
Hamilton, L. D., Barclay, R. K., Wilkins, M. H. F., Brown, G. L., Wilson, H. R., Marvin, D. A., Ephrussi-Taylor, H., and Simmons, N. S., J. Biophys. Biochem. Cytol., 5, 397 (1959).
Langridge, R., J. Cell Physiol., 74, 1 (1969).
Wells, R. D., and Larson, J. E., J. Mol. Biol., 49, 319 (1970).
Szybalski, W., Bøvre, K., Fiandt, M., Guha, A., Hradecna, Z., Kumar, S., Lozeron, H. A., Maher, V. M., Nijkamp, H. J. J., Summers, W. C., and Taylor, K., J. Cell Physiol., 74, 33 (1969).
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MITSUI, Y., LANGRIDGE, R., SHORTLE, B. et al. Physical and Enzymatic Studies on Poly d(I–C).Poly d(I–C), an Unusual Double-helical DNA. Nature 228, 1166–1169 (1970). https://doi.org/10.1038/2281166a0
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DOI: https://doi.org/10.1038/2281166a0
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