Abstract
SMITH1 has compared protein evolution with a popular word game. Just as the object of the game is to pass from one word to another by changing one letter at a time, so in the process of evolution one protein is changed to another by changing only one gene nucleotide at a time. As in the word game each change must result in an English word, so in protein evolution each nucleotide change must result in a viable protein.
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References
Smith, J. M., Nature, 225, 563 (1970).
Salisbury, F. B., Nature, 224, 342 (1969).
Spetner, L. M., IEEE Trans. Information Theory, IT-14, 3 (1968).
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SPETNER, L. Natural Selection versus Gene Uniqueness. Nature 226, 948–949 (1970). https://doi.org/10.1038/226948a0
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DOI: https://doi.org/10.1038/226948a0
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