Abstract
A model is suggested for protein synthesis which depends upon conformational changes in tRNA and allosteric transitions in place of translocation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Watson, J. D., Bull. Soc. Chim. Biol., 46, 1399 (1964).
Erbe, M. S., Nau, M. M., and Leder, P., J. Mol. Biol., 39, 441 (1969).
Gilbert, W., J. Mol. Biol., 6, 389 (1963).
Marcker, K., and Sanger, F., J. Mol. Biol., 8, 935 (1964).
Bretscher, M. S., and Marcker, K. A., Nature, 211, 380 (1966).
Monroe, R. E., J. Mol. Biol., 26, 147 (1967).
Ravel, J. M., Proc. US Nat. Acad. Sci., 57, 1811 (1967).
Hershey, J. W. B., and Thach, R. E., Proc. US Nat. Acad. Sci., 57, 759 (1967).
Pestka, S., and Nirenberg, M. W., J. Mol. Biol., 21, 145 (1966).
Nomura, M., and Lowry, C. B., Proc. US Nat. Acad. Sci., 58, 946 (1967).
Mukundan, M. A., Hershey, J. W. B., Dewey, K. F., and Thach, R., Nature, 217, 1013 (1968).
Ghosh, H. P., Soll, D., and Khorana, H. G., J. Mol. Biol., 25, 275 (1967).
Sonneborn, T. M., in Evolving Genes and Proteins (edit. by Bryson, V., and Vogel, H.), 377 (Academic Press, New York, 1965).
Woese, C., The Genetic Code: the Molecular Basis for Genetic Expression (Harper and Row, New York, 1967).
Goldberg, A. L., and Wittes, R. E., Science, 153, 420 (1966).
Crick, F. H. C., Nature, 213, 119 (1967).
Fuller, W., and Hodgson, A., Nature, 215, 817 (1967).
Kurland, C. G., Science (in the press).
Fellner, P., and Sanger, F., Nature, 219, 236 (1968).
Mangiarotti, G., Apirion, D., Schlessinger, D., and Silengo, L., Biochemistry, 7, 456 (1968).
Gartland, W. J., Ishida, T., Sueoka, N., and Nirenberg, M. W., J. Mol. Biol., 44, 403 (1969).
Adams, A., Lindahl, T., and Fresco, J. T., Proc. US Nat. Acad. Sci., 57, 1684 (1967).
Uhlenbeck, O. C., Baller, J., and Doty, P., Nature, 225, 508 (1970).
Doctor, B. P., Fuller, W., and Webb, N. L. W., Nature, 221, 58 (1969).
Melcher, G., FEBS Lett., 3, 185 (1969).
Levitt, M., Nature, 224, 759 (1969).
Nishizuka, Y., and Lipmann, F., Proc. US Nat. Acad. Sci., 55, 212 (1966).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
WOESE, C. Molecular Mechanics of Translation : a Reciprocating Ratchet Mechanism. Nature 226, 817–820 (1970). https://doi.org/10.1038/226817a0
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1038/226817a0
This article is cited by
-
The ribosome moves: RNA mechanics and translocation
Nature Structural & Molecular Biology (2017)
-
Hypothesis: Emergence of Translation as a Result of RNA Helicase Evolution
Journal of Molecular Evolution (2012)
-
Till termination us do part
Nature (2009)
-
The transorientation hypothesis for codon recognition during protein synthesis
Nature (2002)
-
A ratchet-like inter-subunit reorganization of the ribosome during translocation
Nature (2000)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
