Abstract
ACQUIRED resistance to chemotherapeutic agents is common in the study of bacteria and is a problem of practical significance. Bacteria are resistant to many of the commonly used antibiotics. This can be shown within a few hours by growing bacteria in the presence of the compound1. Virus strains have also been selected in the laboratory which show increased resistance to antiviral agents. Polio strains passed in vivo and in vitro in the presence of guanidine hydrochloride have become up to 1,000 and 10,000 times, respectively, more resistant to inhibition by the drug than the parent strains2, and strains of ECHO 7 and Coxsackie A9 have become more resistant to 2-(α-hydroxybenzyl)benzimidazole after two passes in the presence of the compound3.
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OXFORD, J., LOGAN, I. & POTTER, C. In vivo Selection of an Influenza A2 Strain resistant to Amantadine. Nature 226, 82–83 (1970). https://doi.org/10.1038/226082a0
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DOI: https://doi.org/10.1038/226082a0
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