Abstract
PROTECTIVE malarial antibody has been demonstrated by passive transfer tests in monkey1 and human2 infections and, to a lesser degree, in rodent malaria3–8. Such tests have not, however, provided a suitable basis for detailed studies on the mechanism of malarial immunity. It has been shown recently that serum from monkeys immune to Plasmodium knowlesi specifically inhibits the cyclical proliferation of this simian parasite maintained in vitro9. This technique has now been used to obtain information about levels of protective antibody in immune sera, the distribution of such antibody among the major immuno-globulin classes and its mode of action on the parasite. Cultures of P. knowlesi were initiated with trophozoites and taken through a 24 h cycle of maturation, division, red cell reinvasion and renewed growth9. The average multiplication rate was six-fold in flasks containing normal serum. The course of parasite growth was followed as before by measurement of 3H-leucine incorporation into parasite protein9.
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COHEN, S., BUTCHER, G. Properties of Protective Malarial Antibody. Nature 225, 732–734 (1970). https://doi.org/10.1038/225732a0
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DOI: https://doi.org/10.1038/225732a0
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