Abstract
In eukaryotes, as in prokaryotes, the smaller of the two ribosomal subunits binds mRNA during the initiation of protein synthesis. The formation of the complete initiation complex, sedimenting at 75S, requires GTP, tRNA and initiation factors.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Nomura, M., and Lowry, C. V., Proc. US Nat. Acad. Sci., 58, 946 (1967).
Nomura, M., Lowry, C. V., and Guthrie, C., Proc. US Nat. Acad. Sci., 58, 1487 (1967).
Guthrie, C., and Nomura, M., Nature, 219, 232 (1968).
Grubman, M. J., and Nakada, D., Nature, 223, 1242 (1969).
Kaempfer, R., Meselson, M., and Raskas, H. J., J. Mol. Biol., 31, 277 (1968).
Schlessinger, D., Mangiarotti, G., and Apirion, D., Proc. US Nat. Acad. Sci., 58, 1782 (1967).
Brown, J. C., and Doty, P., Biochem. Biophys. Res. Commun., 30, 284 (1968).
Salas, M., Hille, M. B., Last, J. A., Wahba, A., and Ochoa, S., Proc. US Nat. Acad. Sci., 57, 357 (1967).
Brawerman, G., Revel, M., Salser, W., and Gros, F., Nature, 223, 957 (1969).
Anderson, J. S., Dahlberg, J. E., Bretscher, M., Revel, M., and Clark, B., Nature, 216, 1072 (1967).
Revel, M., Herzberg, M., Becarevic, A., and Gross, F., J. Mol. Biol., 33, 231 (1968).
Greenshpan, H., and Revel, M., Nature, 224, 331 (1969).
Hogan, B. L., and Korner, A., Biochim. Biophys. Acta, 169, 139 (1968).
Kabat, D., and Rich, A., Biochemistry, 8, 3742 (1969).
Joklik, W. K., and Becker, Y., J. Mol. Biol., 13, 496 (1965).
Miller, R. L., and Schweet, R., Arch. Biochem. Biophys., 125, 632 (1968).
Godin, C., Kruh, J., and Dreyfus, J. C., Biochim. Biophys. Acta, 182, 175 (1969).
Heywood, S. M., Cold Spring Harbor Symp. Quant. Biol. (in the press).
Heywood, S. M., and Nwagwu, M., Biochemistry, 8, 3839 (1969).
Von Ehrenstein, G., Methods in Enzymology, 12, 588 (1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HEYWOOD, S. Formation of the Initiation Complex using Muscle Messenger RNAs. Nature 225, 696–698 (1970). https://doi.org/10.1038/225696a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/225696a0
This article is cited by
-
Influence of heating on the formation of ribosome couples and 80S initiation complex from the 40S and 60S ribosomal subunits from rabbit reticulocytes*
Molecular and General Genetics MGG (1974)
-
Translation of Rabbit Globin mRNA
Nature New Biology (1972)
-
Formation of an Initiation Complex with Purified Mammalian Ribosomal Subunits
Nature New Biology (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
