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Immunosuppression by L-Asparaginase

Abstract

L-ASPAHAGINASE, an enzyme which occurs in the serum of certain rodents and is produced by various microorganisms, catalyses the hydrolysis of asparagine to L-aspartic acid and ammonia. It has been found useful in the treatment of acute lymphoblastic leukaemia and in occasional cases of other types of neoplasm in man1.

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References

  1. Adamson, R. H., and Fabro, S., Cancer Chemother. Rep., 52, 617 (1968).

    CAS  PubMed  Google Scholar 

  2. Astaldi, G., Burgio, G. R., Krč, J., Genova, R., and Astaldi, jun., A. A., Lancet, i, 423 (1969).

  3. McElwain, T. J., and Hayward, S. K., Lancet, i, 527 (1969).

  4. Jerne, N. K., and Nordin, A. A., Science, 140, 405 (1963).

    Article  ADS  PubMed  Google Scholar 

  5. Broome, J. D., Brit. J. Cancer, 22, 595 (1968).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Berenbaum, M. C., Brit. J. Cancer, 23, 426 (1969).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Broome, J. D., J. Nat. Cancer Inst., 35, 967 (1965).

    CAS  PubMed  Google Scholar 

  8. Bruce, W. R., Meeker, B. E., Powers, W. E., and Valeriote, F. A., J. Nat. Cancer Inst., 42, 1015 (1969).

    CAS  PubMed  Google Scholar 

  9. Rall, D. P., and Homan, E. R., Cancer Chemother. Rep., 51, 247 (1967).

    CAS  PubMed  Google Scholar 

  10. Valeriote, F. A., Bruce, W. R., and Meeker, B. E., Biophys. J., 6, 145 (1966).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Madoc-Jones, M., and Bruce, W. R., Nature, 215, 302 (1967).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Valeriote, F. A., and Bruce, W. R., J. Nat. Cancer Inst., 38, 393 (1967).

    CAS  PubMed  Google Scholar 

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BERENBAUM, M. Immunosuppression by L-Asparaginase. Nature 225, 550–552 (1970). https://doi.org/10.1038/225550a0

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