Abstract
TRANSPLANTATION leads to graft versus host reactions in the recipient which can, however, frequently be overcome by application of antilymphocytic serum (ALS) raised against the lymphocytes of the recipient. This has been successful in the heterotransplantation of human skin1 and human foetal tissue2 in mice. Floersheim et al.3 succeeded in the transplantation of homologous bone marrow in mice treated with cytotoxic drugs and ALS before the haemopoietic cells were grafted. Repopulation of the recipients with donor haemopoietic cells was demonstrated.
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Lance, E. M., and Medawar, P. B., Lancet, i, 1174 (1968).
Phillips, B., and Gazet, J. C., Nature, 222, 1292 (1969).
Floersheim, G. L., and Ruskiewicz, M., Nature, 222, 854 (1969).
Till, J. E., and McCulloch, E. A., Radiat. Res., 14, 213 (1961).
Dacie, J. V., and Lewis, S. M., Practical Hematology, fourth ed. (Churchill, London, 1968).
Coombs, R. R. A., Marks, J., and Bedford, D., Brit. J. Haemat., 2, 84 (1956).
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LOUWAGIE, A., VERWILGHEN, R. Growth of Haemopoietic Spleen Colonies after Grafting of Human Bone Marrow in Mice. Nature 225, 383 (1970). https://doi.org/10.1038/225383a0
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DOI: https://doi.org/10.1038/225383a0
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