Abstract
AFTER paternal exposure to mutagens and subsequent mating, adverse genetic effects are seen in the form of pre-implantation losses of fertilized ova and zygotes, early foetal deaths, and sterility and semi-sterility in F1 progeny1. Early foetal deaths are a direct quantitative index of dominant lethal mutations. These are generally concomitant with pre-implantation losses, which thus constitute a presumptive but less specific measure of mutagenicity1. A practical, sensitive assay for mutagens, based, on the induction of dominant lethal mutations in mammals, has been developed and applied to a wide range of environmental chemical pollutants and to drugs2.
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EPSTEIN, S., JOSHI, S., ARNOLD, E. et al. Abnormal Zygote Development in Mice after Paternal Exposure to a Chemical Mutagen. Nature 225, 1260–1261 (1970). https://doi.org/10.1038/2251260a0
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DOI: https://doi.org/10.1038/2251260a0
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