Abstract
IT is commonly accepted that ovulation is a result of a-relatively abrupt release of luteinizing hormone (LH), brought about by the action on the pituitary gland of a specific neurohumour of hypothalamic origin—luteinizing hormone releasing factor (LRF)1. It is also believed that ovarian hormones are involved in the activation of the neurosecretory process2. On the basis of the facilitating action of oestrogen on ovulation in immature3 and 5-day cyclic2 rats, a positive feedback action of oestrogen has been implicated in the functional integration of hypothalamus, pituitary and ovaries in spontaneously ovulating species. Evidence in support of this concept has now been obtained from experiments with a compound, ICI 46,474 [trans -1 (p-β-dimethylaminoethoxyphenyl)-1,2-diphenyl-but-1-ene] which, in rats, is a potent antagonist of oestrogen4.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Harris, G. W., and Campbell, H. J., in The Pituitary Gland, 2, 199 (Butter-worths, 1966).
Everett, J. W., in Sex and Internal Secretions, third ed., 1, 497 (Williams and Wilkins, 1961).
Hohlweg, W., Klin. Wschr., 13, 92 (1934).
Walpole, A. L., J. Reprod. Fert. Supplement, 4, 3 (1968).
Gregory, H., Walpole, A. L., Charlton, H. M., Harris, G. W., and Reed, M., in Pharmacology of Hormonal Polypeptides and Proteins, 123 (Plenum Press, 1968).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
LABHSETWAR, A. Role of Oestrogen in Spontaneous Ovulation demonstrated by Use of an Antagonist of Oestrogen, ICI 46,474. Nature 225, 80–81 (1970). https://doi.org/10.1038/225080a0
Received:
Issue Date:
DOI: https://doi.org/10.1038/225080a0
This article is cited by
-
Tamoxifen: a most unlikely pioneering medicine
Nature Reviews Drug Discovery (2003)
-
Effects of Serotonin on Spontaneous Ovulation in Rats
Nature (1971)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
