Abstract
LITHIUM is effective in the treatment of manic and other psychotic disorders1–3. The recommended human dose is 90–1,800 mg daily, with serum lithium concentrations of 0.6–1.6 milliequivalents/litre4. Lithium salts have been found to be teratogenic in amphibians5,6 and chicks7 but not in mice8,10 or rats9. Johansen and Ulrich10 have, however, found that lithium is able to cross the placental barrier in rats, and that its concentration in the serum of foetuses was half of the serum concentration in their mothers who received lithium in the diet. I now report the teratogenic effect of lithium carbonate in mice11.
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SZABO, K. Teratogenic Effect of Lithium Carbonate in the Foetal Mouse. Nature 225, 73–75 (1970). https://doi.org/10.1038/225073a0
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DOI: https://doi.org/10.1038/225073a0
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