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Inhibition of the Growth of Murine Malignant Melanoma with Synthetic Double-stranded Ribonucleic Acid

Nature volume 224, pages 372–373 (1969)Cite this article

Abstract

WE wish to report a potential method for the treatment of malignant melanomas which, unlike others that have been proposed1,2, is independent of melanin content or tyrosinase activity in the tumours. The double-stranded homopolymer, polyinosinic–polycytidylic acid (poly I. poly C), given parenterally, has been shown to inhibit the growth of several malignant murine tumours3,4. We sought to determine whether poly I.poly C is also active against amelanotic murine malignant melanoma.

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Authors and Affiliations

  1. Department of Dermatology, New York University School of Medicine,

    ROBERT S. BART & ALFRED W. KOPF

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  1. ROBERT S. BART
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  2. ALFRED W. KOPF
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BART, R., KOPF, A. Inhibition of the Growth of Murine Malignant Melanoma with Synthetic Double-stranded Ribonucleic Acid. Nature 224, 372–373 (1969). https://doi.org/10.1038/224372a0

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