Abstract
ELECTROPHYSIOLOGICAL experiments have shown the presence of electrical coupling between non-excitable cells in a number of embryonic systems and there is currently considerable interest in the significance of such coupling in relation to the control of growth and differentiation1. One approach described here which might prove useful in assessing the importance of low resistance junctions during development involves the treatment of such coupled cells with agents which will “uncouple” them, followed by careful observation of subsequent development.
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References
Furshpan, E. J., Current Topics in Developmental Biology, 3 (1968).
Loewenstein, W. R., Ann. NY Acad. Sci., 137, 441 (1966).
Hauswirth, O., J. Physiol., 201, 42P (1969).
Allison, A. C., and Nunn, J. F., Lancet, ii, 1326 (1968).
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PALMER, J., SLACK, C. Effect of ‘Halothane’ on Electrical Coupling in Pregastrulation Embryos of Xenopus laevis. Nature 223, 1286–1287 (1969). https://doi.org/10.1038/2231286a0
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DOI: https://doi.org/10.1038/2231286a0
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