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Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides

Nature volume 222, pages 1148–1152 (1969)Cite this article

Abstract

Several polyribonucleotides, both as single species and when annealed in pairs, are able to induce interferon production in mammalian cells and cellular resistance to virus infection. These studies suggest that a stable secondary, presumably multistranded structure is required for this activity.

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Author notes

  1. E. DE CLERCQ: Lilly International Fellow, aspirant of the Belgian N.F.W.O. (Nationaal Fonds voor Wetenschappelijk Onderzoek).

Authors and Affiliations

  1. Division of Infectious Diseases, Department of Medicine, Stanford University School of Medicine, Stanford, California

    E. DE CLERCQ & T. C. MERIGAN

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  1. E. DE CLERCQ
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CLERCQ, E., MERIGAN, T. Requirement of a Stable Secondary Structure for the Antiviral Activity of Polynucleotides. Nature 222, 1148–1152 (1969). https://doi.org/10.1038/2221148a0

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