Abstract
THE rejection of skin grafts has been a standard laboratory test for histocompatibility for many years. It is now clear, however, that not all transplanted organs behave in the same way as skin; the pig, for example, rapidly rejects a skin or kidney graft from another member of the species, but only rejects a liver transplant very slowly, if at all1. Likewise, rats of the Lewis and Fisher strains will reject skin grafts exchanged between them, but are quite unable to reject kidney transplants2. With a more “incompatible” strain combination, such as Lewis and Brown Norway, kidney transplants are rejected although the occasional rat survives for up to 30 days3.
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References
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SALAMAN, J. Renal Transplantation between Two Strains of Rats. Nature 220, 930–931 (1968). https://doi.org/10.1038/220930a0
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DOI: https://doi.org/10.1038/220930a0
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