Abstract
ALTHOUGH heterospecific antilymphocytic IgG can suppress the development of immunity to antigens of various kinds, including inter alia immunity in rodents to alum-precipitated bovine serum albumin, it is itself strongly antigenic. Thus it has been shown that animals which have received injections of antilymphocytic globulin develop antibody to globulins of the species in which this material was raised2,3 and also show rapid elimination of isotopically labelled normal and antilymphocytic IgG from this species4,5. Some experiments have been carried out to try to resolve this apparent paradox.
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HOWARD, R., ASFIS, N. & WOODRUFF, M. Comparative Immunogenicity of Antilymphocytic Globulin in Solution and adsorbed on Lymphocytes. Nature 220, 816–818 (1968). https://doi.org/10.1038/220816a0
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DOI: https://doi.org/10.1038/220816a0
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