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High Lymphocyte Transformation with Non-haemolytic Streptococcal Product

Nature volume 219, pages 757–758 (1968)Cite this article

Abstract

A VARIETY of antigenic substances can induce generally low percentages of transformation of peripheral blood lymphocytes obtained from specifically sensitive donors into large blast-like cells capable of division. Phytohaemagglutinin, pokeweed extract, streptolysin S, staphylococcal filtrate and antilymphocyte serum are capable of inducing generally higher percentages of transformation in the lymphocytes of all normal subjects, apparently irrespective of previous sensitization (reviewed in ref. 1). Streptolysin S, a haemolytic streptococcal toxin, is of interest because it has been implicated in the pathogenesis of rheumatic fever2 and lysosome-mediated tissue damage3. We report here the induction of a high percentage of transformation of human peripheral blood lymphocytes cultured in vitro with a non-haemolytic streptococcal product.

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Author notes

  1. F. QUAGLIATA

    Present address: Kennedy Institute of Rheumatology, London

Authors and Affiliations

  1. Irvington House Institute and the Department of Medicine, New York University School of Medicine, New York

    A. TARANTA, G. CUPPARI & F. QUAGLIATA

Authors
  1. A. TARANTA
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  2. G. CUPPARI
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  3. F. QUAGLIATA
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TARANTA, A., CUPPARI, G. & QUAGLIATA, F. High Lymphocyte Transformation with Non-haemolytic Streptococcal Product. Nature 219, 757–758 (1968). https://doi.org/10.1038/219757a0

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  • DOI: https://doi.org/10.1038/219757a0

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