Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Ionic Permeability of the Guinea-pig Taenia Coli Muscle

Nature volume 219, pages 732–733 (1968)Cite this article

Abstract

WITHIN less than 2 yr, two diametrically conflicting views of the ionic permeability of the guinea-pig taenia coli muscle have been published in Nature1,2. The first1 assumed by analogy with frog skeletal muscle3–5 that the membrane is permeable to Cl. The intracellular Cl was then calculated from Donnan considerations and the values so obtained seemed to agree quite well with estimates based on electrophysiological measurements of inhibitory postsynaptic potentials. The second report2 does not refer to the first, but it confirms still earlier data6 on the “anomalous” osmotic behaviour of taenia coli muscles. The muscles do not gain weight on prolonged exposure to isosmotic KCl-enriched media. They lose weight when exposed to media that are made hyperosmotic by addition of KCl.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Bennett, M. R., Nature, 211, 1149 (1966).

    Article  ADS  CAS  Google Scholar 

  2. Brading, A. F., and Tomita, T., Nature, 218, 276 (1968).

    Article  ADS  CAS  Google Scholar 

  3. Boyle, P. J., and Conway, E. J., J. Physiol., 100, 1 (1941).

    Article  CAS  Google Scholar 

  4. Hodgkin, A. L., and Horowicz, P., J. Physiol., 148, 127 (1959).

    Article  CAS  Google Scholar 

  5. Reuben, J. P., Lopez, E., Brandt, P. W., and Grundfest, H., Science, 142, 246 (1963).

    Article  ADS  Google Scholar 

  6. Casteels, R., and Kuriyama, H., J. Physiol., 184, 120 (1966).

    Article  CAS  Google Scholar 

  7. Reuben, J. P., Girardier, L., and Grundfest, H., J. Gen. Physiol., 47, 1141 (1964).

    Article  CAS  Google Scholar 

  8. Gainer, H., and Grundfest, H., J. Gen. Physiol., 51, 399 (1968).

    Article  CAS  Google Scholar 

  9. Lang, M. A., and Gainer, H., Fed. Proc., 27, 701 (1968).

    Google Scholar 

  10. Freeman, A. R., Reuben, J. P., Brandt, P. W., and Grundfest, H., J. Gen. Physiol., 50, 423 (1966).

    Article  CAS  Google Scholar 

  11. Grundfest, H., Fed. Proc., 26, 1613 (1967).

    CAS  PubMed  Google Scholar 

  12. Kuriyama, H., J. Physiol., 166, 15 (1963).

    Article  CAS  Google Scholar 

  13. Freeman, A. R., and Grundfest, H., Fed. Proc., 25, 570 (1966).

    Google Scholar 

  14. Dunham, P. B., Freeman, A. R., and Grundfest, H., Biol. Bull., 133, 462 (1967).

    Google Scholar 

  15. Freeman, A. R., and Dunham, P. B., Fed. Proc., 27, 703 (1968).

    Google Scholar 

  16. Grundfest, H., in Advances in Comparative Physiology and Biochemistry (edit. by Lowenstein, O. E.), 2, 1 (Academic Press, New York, 1966).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Neurophysiology, Department of Neurology, College of Physicians and Surgeons, Columbia University,

    H. GRUNDFEST

Authors
  1. H. GRUNDFEST
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

GRUNDFEST, H. Ionic Permeability of the Guinea-pig Taenia Coli Muscle. Nature 219, 732–733 (1968). https://doi.org/10.1038/219732a0

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1038/219732a0

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing