Abstract
THIS communication describes the inhibition in rabbits of the primary immune response to the isophile antigen of sheep red cells by passively given anti-Forssman antibody. It is well established that antibody, administered at or about the same time as antigen can suppress the primary immune response to the antigen. Antibody given as long as 40 days after antigen is capable of reducing the number of antibody producing cells1. The mechanism by which passively given antibody suppresses the immune response remains obscure. Whatever the mode of action—whether by feed-back mechanism, by causing phagocytosis and destruction of antigen, or by competing with antibody producing cells for the capture of antigen—it is generally supposed that antibody acts only specifically, that is, it is only able to suppress the response to the antigen at which it is directed.
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References
Wigzell, H., J. Exp. Med., 124, 953 (1966).
Brody, N. I., Walker, J. G., and Siskind, G. W., J. Exp. Med., 126, 81 (1967).
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GREENBURY, C., MOORE, D. Non-specific Antibody-induced Suppression of the Immune Response. Nature 219, 526–527 (1968). https://doi.org/10.1038/219526a0
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DOI: https://doi.org/10.1038/219526a0
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