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Antiviral Properties of 1-Phenoxymethyl-3,4-Dihydro and 1,2,3,4-Tetrahydroisoquinolines

Abstract

THERE are few clinically effective antiviral compounds (5-iodo-2′-deoxyuridine1, N-methyl isatin thiosemicarbazone2, adamantanamine3–5) and they all have the disadvantage of possessing only a narrow spectrum of activity. In human respiratory viral infection, where it is not possible without laboratory investigation to identify precisely the responsible pathogen (and then only in restrospect), it would be useful to have a compound which possessed a spectrum of activity embracing many of the viruses known to be commonly involved.

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BRAMMER, K., MCDONALD, C. & TUTE, M. Antiviral Properties of 1-Phenoxymethyl-3,4-Dihydro and 1,2,3,4-Tetrahydroisoquinolines. Nature 219, 515–517 (1968). https://doi.org/10.1038/219515a0

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