Abstract
FOLLOWING the report of Halpern et al.1 that single or repeated injection of a killed suspension of a strain of Cornyebacterium parvum causes intense stimulation of lymphoreticular tissues, it was shown in our laboratory2 that intravenous injection of the same material either 2 days before or 8–12 days after subcutaneous inoculation of 105 or 104 viable mammary carcinoma cells in A strain mice significantly delayed the appearance of the tumour. Subsequently Halpern et al.3 found that the same strain of C. parvum markedly inhibited the growth of a transplanted mouse sarcoma.
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References
Halpern, B. N., Prevot, A.-R., Biozzi, G., Stiffel, C., Mouton, D., Morard, J. C., Bouthillier, Y., and Decreusefond, C., J. Reticulo-endothelial Soc., 1, 77 (1963).
Woodruff, M. F. A., and Boak, J. L., Brit. J. Cancer, 20, 345 (1966).
Halpern, B. N., Biozzi, G., Stiffel, C., and Mouton, D., Nature, 212, 853 (1966).
Bailey, N. T. J., Statistical Methods in Biology (English Universities Press, London, 1959).
Biozzi, G., Benacerraf, B., Stiffel, C., and Halpern, B. N., CR Soc. Biol., 148, 431 (1954).
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SMITH, L., WOODRUFF, M. Comparative Effect of Two Strains of C. parvum on Phagocytic Activity and Tumour Growth. Nature 219, 197–198 (1968). https://doi.org/10.1038/219197a0
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DOI: https://doi.org/10.1038/219197a0
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