Abstract
Pattison and Jones1 suggested that the scrapie agent is present in normal tissues and “unmasked” in the pathogenesis of the scrapie lesions, and this is at first sight attractive. If it is accepted that the lesions of scrapie can on occasion be induced by the inoculation of normal tissues, even with the irregularity described, one is reminded of the early history of experimental allergic encephalomyelitis before the use of adjuvants2. The fact that the phenomenon is not regularly reproducible is not by itself conclusive. It should be emphasized, however, that there is no evidence that experimental scrapie is influenced by the addition of adjuvants to the inocula3,4.
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MACKAY, J. Detection of the Scrapie Agent in Tissues of Normal Mice. Nature 219, 182–183 (1968). https://doi.org/10.1038/219182a0
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DOI: https://doi.org/10.1038/219182a0
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