Abstract
PRELIMINARY studies of the changes in crystallin proteins occurring during development of the lens have indicated that the α-crystallins of foetal, calf and adult lenses differ in their chromatographic properties when fractionated on DEAE-cellulose1. The studies reported here indicate that the types of subunits present in bovine α-crystallins change during lens development. In a previous study, we showed that the α-crystallins can be resolved into five components by DEAE-cellulose chromatography, and that these multiple forms of α-crystallin contain identical subunit chains2. As they vary only in their proportions of these subunits, we have combined the five α-crystallin components into one fraction in the following experiments in order to get an overall picture of the types of α-crystallin subunits produced at different stages of development.
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References
Palmer, W. G., and Papaconstantinou, J., (International Society for Cell Biology, Symposium on Differentiation and Immunology (edit. by Warren, K. B.), 7 (Academic Press, New York, 1968) (in the press).
Palmer, W. G., and Papaconstantinou, J., Biochemistry, 7, 243 (1968).
Bloemendal, H., Bont, W. S., Jongkind, J. F., and Wisse, J. H., Exp. Eye Res., 1, 300 (1962).
Björk, I., Exp. Eye Res., 3, 1 (1964).
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PALMER, W., PAPACONSTANTINOU, J. Increase in the Complexity of α-Crystallins during Differentiation of Lens Cells . Nature 219, 170–172 (1968). https://doi.org/10.1038/219170a0
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DOI: https://doi.org/10.1038/219170a0
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