Abstract
Of nine antimicrobial agents introduced intravenously into sixteen dogs, only the basic macrolides erythromycin and oleandomycin readily crossed the prostatic epithelium into the prostatic fluid. A suitable drug for curing chronic bacterial prostatitis with bladder bacteriuria must be lipid soluble, have a pKa of 8.6 or more, and have optimal activity against Gram-negative bacteria at pH 6.6.
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WINNINGHAM, D., NEMOY, N. & STAMEY, T. Diffusion of Antibiotics from Plasma into Prostatic Fluid. Nature 219, 139–143 (1968). https://doi.org/10.1038/219139a0
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DOI: https://doi.org/10.1038/219139a0
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