Abstract
STRUCTURAL requirements for the antigenicity of the Rh antigens of human erythrocytes have not been recognized so far. Recent evidence based on the reversible loss of antigenicity as a result of treatment with sulphydryl reagents suggested that sulphydryl groups are required for activity1. Clear evidence of the activity of the Rh antigens in solution has not been found. The presence of sulphydryl groups suggests that protein is the class to which the chemical structure of the Rh antigens belongs. This is in contrast to previous work which suggested that carbohydrate moieties were responsible for the specificity of the Rh antigen2.
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GREEN, F. Rh Antigenicity: an Essential Component soluble in Butanol. Nature 219, 86–87 (1968). https://doi.org/10.1038/219086a0
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DOI: https://doi.org/10.1038/219086a0
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