Abstract
ATTEMPTS to demonstrate differences in specificity of 19S and 7S antibodies have produced conflicting results. For example, recent reports refer to (i) greater specificity of 7S than 19S rabbit antibodies in agglutination tests with strains of Shigella flexneri1; (ii) similar specificities with these two antibodies in complement-fixation tests with rabbit antibody fractions to Southern bean mosaic virus2; (iii) specific 19S antibody, in haemagglutination-inhibition (HI) tests, against mumps virus in monkeys previously immune to the antigenically related DA virus, in the presence of 7S antibody equally reactive with both viruses3; and (iv) 19S rabbit antibodies to SW influenza virus which showed high cross-reactivity with related viruses compared with relatively specific early 7S antibody, both in HI and neutralization tests4. Because of the strong serological cross-reactivity of group B arboviruses, especially in HI tests, efforts to improve group B antibody specificity have employed rather tedious antigen absorptions5,6, an indirect HI test using erythrocytes presensitized with each antigen of interest7, or Casals's8 kinetic HI test9,10 which uses a checker-board arrangement for each antigen–antibody reaction and hence becomes rather cumbersome.
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WESTAWAY, E. Greater Specificity of 19S than 7S Antibodies on Haemagglutination-Inhibition Tests with Closely Related Group B Arboviruses. Nature 219, 78–79 (1968). https://doi.org/10.1038/219078a0
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DOI: https://doi.org/10.1038/219078a0
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