Abstract
IF ionizing radiation is delivered in fractions, cells usually recover from “sub-lethal damage” inflicted by one dose during the time which elapses before the next dose is given. This phenomenon has been observed with many types of cell, ranging from micro-organisms to higher cells in organized tissues1–4. In many experimental systems, this phenomenon has been studied by comparing the effects of two doses, separated by varying intervals of time, with those of the more damaging single total dose of equal magnitude. The dose required to produce a given effect must be increased if oxygen is excluded from the irradiated system; but the extent of recovery after a given amount of damage has in several instances been the same, whether or not oxygen was present during irradiation (refs. 5 and 6 and unpublished results of A. Howard). Some results have, however, been recorded in which the absence of oxygen during irradiation resulted in less recovery from sub-lethal damage3,7.
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BRYANT, P. Survival after Fractionated Doses of Radiation: Modification by Anoxia of the Response of Chlamydomonas. Nature 219, 75–77 (1968). https://doi.org/10.1038/219075b0
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DOI: https://doi.org/10.1038/219075b0
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